Antibacterial activity of some Serbian aromatic plants in relation to selected phytopathogenic bacteria (2025)

Editorial: Discovery of novel plant-derived compounds with antibacterial actions against antibiotic-resistant bacteria, volume II

Frontiers in Microbiology, 2022

Editorial on the Research Topic Discovery of novel plant-derived compounds with antibacterial actions against antibiotic-resistant bacteria, volume II The wide and even abuse of antimicrobials in medicine and agriculture has led to severe widespread antimicrobial resistance, causing reduced effectiveness or even ineffectiveness of many antibacterial agents (Hobson et al., 2021). Therefore, it is essential and urgent to discover novel antibacterial agents that can effectively fight against antibiotic-resistant bacteria. Nature is a reservoir for diverse antimicrobial agents. Our and other recent research indicates that numerous medicinal plants, spices, and their bioactive compounds possess antibacterial properties (

Antimicrobial compounds from plants

Fighting Antimicrobial Resistance, 2018

Plant-Derivatives Small Molecules with Antibacterial Activity

Antibiotics

The vegetal world constitutes the main factory of chemical products, in particular secondary metabolites like phenols, phenolic acids, terpenoids, and alkaloids. Many of these compounds are small molecules with antibacterial activity, although very few are actually in the market as antibiotics for clinical practice or as food preservers. The path from the detection of antibacterial activity in a plant extract to the practical application of the active(s) compound(s) is long, and goes through their identification, purification, in vitro and in vivo analysis of their biological and pharmacological properties, and validation in clinical trials. This review presents an update of the main contributions published on the subject, focusing on the compounds that showed activity against multidrug-resistant relevant bacterial human pathogens, paying attention to their mechanisms of action and synergism with classical antibiotics.

Chapter 10 ANTIMICROBIAL COMPOUNDS FROM PLANTS

2018

Plants as sources of new antimicrobials and resistance-modifying agents

Natural Product Reports, 2012

Infections caused by multidrug-resistant bacteria are an increasing problem due to the emergence and propagation of microbial drug resistance and the lack of development of new antimicrobials. Traditional methods of antibiotic discovery have failed to keep pace with the evolution of resistance. Therefore, new strategies to control bacterial infections are highly desirable. Plant secondary metabolites (phytochemicals) have already demonstrated their potential as antibacterials when used alone and as synergists or potentiators of other antibacterial agents. The use of phytochemical products and plant extracts as resistance-modifying agents (RMAs) represents an increasingly active research topic. Phytochemicals frequently act through different mechanisms than conventional antibiotics and could, therefore be of use in the treatment of resistant bacteria. The therapeutic utility of these products, however, remains to be clinically proven. The aim of this article is to review the advances in in vitro and in vivo studies on the potential chemotherapeutic value of phytochemical products and plant extracts as RMAs to restore the efficacy of antibiotics against resistant pathogenic bacteria. The mode of action of RMAs on the potentiation of antibiotics is also described. 7

Reviews on challenges, opportunities and future prospects of antimicrobial activities of medicinal plants: Alternative solutions to combat antimicrobial resistance

International Journal of Herbal Medicine, 2019

The effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi, and at country level worldwide both in humans and animals was endangered by the emergence of conventional antimicrobial resistance. As result, the world interestingly, forward-looking to the natural products of medicinal plants as alternative remedies in the field of medical sciences in view of the novel molecules delivered by this discipline of science. In spite of the fact that, traditional medicinal healers have used medicinal plants for treatment of different ailments for centuries, there has always been a frequently asked question about their therapeutic efficacy, validation and standardization. Therefore, the main objective of this paper is to review and enlighten challenges, opportunities and future prospects of antimicrobial activities of medicinal plants as alternative solutions to combat antimicrobial resistance worldwide in humans as well as animals. Moreover, a continuous and progressing systematic researches and investigation using standardized extract develop through advanced analytical procedures need to be conducted to prove the biological ingredients and test the safety, efficiency and to determine the types of compounds responsible for the antimicrobial effects of these medicinal plants will be desirable.

Medicinal Plants as Alternative Sourcesof Therapeutics against Multidrug-Resistant Pathogenic Microorganisms Based on Their Antimicrobial Potential and SynergisticProperties

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components, 2013

Academic Press is an imprint of Elsevier

Targeted Screening of Bioactive Plant Extracts and Phytocompounds Against Problematic Groups of Multidrug-Resistant Bacteria

Modern Phytomedicine, 2006

The use of the medicinal plants in the treatment of human diseases is an age-old practise in traditional systems of medicine throughout the world. Medicinal plants are an important source of diverse bioactive and therapeutic compounds, and the recent increase in the numbers of multidrug-resistant (MDR) bacteria has triggered immense interest in new drugs or preparations from natural sources, including plants. Particularly problematic groups of MDR bacteria include methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), â-lactamase-producing enteric bacteria (E. coli, Salmonella, Klebsiella, Shigella spp.) and other MDR Pseudomonas spp., Campylobacter spp., and Mycobacterium tuberculosis. Excessive and indiscriminate use of antibiotics has led to the development of such drug-resistant bacteria both in hospitals and communities all over the world.

Antibacterial Activitiesof Medicinal Plant Extracts Against Various Microorganisms and Multi Drug Resistant Phenotypes

2021

Interest in medicinal plants showing synergism with antibiotics or as an alternative to antibiotics as possible industrial product is receiving major importance. Medicinal plants are finding their way into pharmaceuticals, cosmetics, and neutraceuticals. Long before mankind discovered the existence of microbes, the idea that certain plants had healing potential, indeed, that they contained what we would currently characterize as antimicrobial principles, was well accepted. Since antiquity, man has used plants to treat common infectious diseases and some of these traditional medicines are still included as part of the habitual treatment of various maladies. Today’s ,microbial infections ,resistance to antibiotic drugs have been the biggest challenges, which threaten the health of societies. It has become widely recognized that antimicrobial resistance(AMR) is one of the biggest health threats that mankind faces encompassing huge health and economic burdens on governments and societie...

Plants as potential source of antimicrobial agents

For microbial infections, either caused by bacteria or fungi, antibiotics are employed. After the discovery of antibiotics it was thought that infectious diseases will no longer exist. But due to irrational use of antibiotics, a number of bacterial strains with multi-drug resistance have emerged (khan et al., 2009) and due to infectious diseases millions of people die every year (Dubey et al., 2012). It is a bitter fact that infectious diseases are the leading cause of the premature deaths which result in approximately fifty thousand deaths annually around the globe (Ahmad and Beg, 2001). The unnoticeable use of antimicrobials both in developing and developed countries led to the creation of microbial resistance problems. It also makes the treatment difficult especially in immunocompromised patients (Ahmad and Beg, 2001).